Background Data
Prevalence and Relative Risk Estimates Used in Calculators
Prostate Cancer:
Category |
Prevalence |
Relative Risk (Ref) |
| Any FH (Black): | 5.5% (Whitmore) | 2.6 (Whitmore) |
| Any FH (White): | 7.4% (Whitmore) | 1.9 (Whitmore) |
| Any FH (Asian): | 3.6% (Whitmore) | 2.7(Whitmore) |
| Father (US White, UK, Aust) | Not applicable | 2.50 (Johns) |
| Brother (US White, UK, Aust) | Not applicable | 3.40 (Johns) |
| Father & Brother (US White, UK, Aust) | Not applicable | 3.50 (Johns) |
Breast Cancer:
Category |
Prevalence |
Relative Risk (Ref) |
| Any Family History (FH) (<60) | 10.4% (X) | 2.4 (Beral) |
| Any Family History (FH) (>=60) | 11.2% (X) | 1.9 (?Beral) |
| User aged >=50 | User age less than 50 | |
| Mother (<50) | 1.7 | 2.5 (Pharoah) |
| Mother (>=50) | 1.7 | 1.6 (Pharoah) |
| Sister (<50) | 1.8 | 3.3(Pharoah) |
| Sister (>=50) | 1.9 | 3.0 |
| Daughter (any age) | 1.8 | 1.8 |
| Mother and Sister (any age) | 3.6 | 3.6 |
| One 1st degree and one 2nd degree relative (any age) |
2.5 | 3.1 |
| One 2nd degree relative (any age) | 1.6 | 1.7 |
| Two 2nd degree relatives (any age) | 2.2 | 2.4 |
| HRT Type (E-only) | HRT (E+P) | |
| < 1 year | 1.0 | 1.45 |
| 1-4 years | 1.25 | 1.74 |
| 5-9 years | 1.32 | 2.17 |
| 10+ years | 1.45 | 2.31 |
The prevalence of HRT use was based on age and duration and type for Australia (ref: Coombes, BMJ refe) and USA (Coombes California paper)
